Genomic Imprinting: Implications for Human Disease

Implications of genomic imprinting for psychiatric genetics.

The genetics of psychiatric disease continues to be puzzling; what, for instance, really is the mode of transmission of schizophrenia? Is it polygenic (Gottesman & Shields, 1982)? Is it dominant but incompletely penetrant (Book, 1953), or partly dominant with incomplete penetrance (Slater, 1958); does it involve two loci with epistasis (Matthysse & Kidd, 1976), or is it none of these (O'Rourke ...

Implications of genomic imprinting for psychiatric genetics

The genetics of psychiatric disease continues to be puzzling; what, for instance, really is the mode of transmission of schizophrenia? Is it polygenic (Gottesman & Shields, 1982)? Is it dominant but incompletely penetrant (Book, 1953), or partly dominant with incomplete penetrance (Slater, 1958); does it involve two loci with epistasis (Matthysse & Kidd, 1976), or is it none of these (O'Rourke ...

Genomic Imprinting and Human Reproduction

Genomic Imprinting in Human Placenta

Luca Lambertini1,2, Men-Jean Lee3, Carmen J. Marsit4 and Jia Chen1,5,6 1Department of Preventive Medicine, Mount Sinai School of Medicine, New York, 2Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, 3Department of Obstetrics and Gynecology, Indiana University-Purdue University, Indianapolis, 4Department of Pharmacology and Toxicology, Dart...

Parental origin effects in human trisomy for chromosome 14q: implications for genomic imprinting.

Parental origin specific congenital anomalies have been noted in patients with uniparental disomy of the long arm of human chromosome 14 (UPD14). This suggests the presence of imprinted genes, consistent with observations of imprinting in the region of syntenic homology in the mouse. It is not known whether the distinct defects reported for paternal and maternal UPD14 are the result of bialleli...